' 
SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8
USERS' SCORE
Good
Based on 6 Reviews
8.5
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Iron (elemental) (from 90 mg Ferrous Bisglycinate)(Ferrochel™)
18 mg
100%
Top Medical Research Studies
9
Rubiadin reduces liver iron overload
Rubiadin Mediates the Upregulation of Hepatic Hepcidin and Alleviates Iron Overload via BMP6/SMAD1/5/9-Signaling Pathway.
Study highly relevant to liver disease
We explored the effects of rubiadin, a beneficial compound derived from a Chinese herb, on iron metabolism and its implications for liver disease. Recognizing the challenges posed by iron overload diseases, we aimed to discover a safe approach to manage excessive iron accumulation in the body. Through experiments involving various analyses, we observed that rubiadin significantly downregulated proteins that are typically elevated in conditions of high iron, such as transferrin receptor 1 and ferroportin 1.
Furthermore, when we administered rubiadin to mice with iron overload, it resulted in decreased serum and duodenal iron levels and an increase in hepcidin mRNA expression in the liver. This suggests that rubiadin may not only help the body regulate iron better but might also protect against the harmful effects of excess iron.
Our research also delved into the mechanisms behind these effects. We found that rubiadin-induced hepcidin expression was mediated through a specific signaling pathway involving bone morphogenetic protein 6 (BMP6) and SMAD proteins. The ability of rubiadin to enhance hepcidin levels points toward a promising natural strategy for tackling iron overload in liver diseases and could have broader implications for treating related conditions.
Furthermore, when we administered rubiadin to mice with iron overload, it resulted in decreased serum and duodenal iron levels and an increase in hepcidin mRNA expression in the liver. This suggests that rubiadin may not only help the body regulate iron better but might also protect against the harmful effects of excess iron.
Our research also delved into the mechanisms behind these effects. We found that rubiadin-induced hepcidin expression was mediated through a specific signaling pathway involving bone morphogenetic protein 6 (BMP6) and SMAD proteins. The ability of rubiadin to enhance hepcidin levels points toward a promising natural strategy for tackling iron overload in liver diseases and could have broader implications for treating related conditions.
Read More
7
Iron's impact on liver disease
Long-term iron supplementation in four patients with X-linked erythropoietic protoporphyria: associations with serum proteins and erythrocyte protoporphyrin levels-a single-centre retrospective study.
Focus on liver treatment effects
We explored the long-term effects of iron supplementation in four patients suffering from X-linked erythropoietic protoporphyria (XLEPP), a rare genetic disorder that can lead to serious liver problems due to the buildup of a substance called protoporphyrin IX (PPIX) in the blood. This condition often causes severe photosensitivity and can result in liver damage, which, in some cases, may necessitate a liver transplant.
By providing iron, which is essential for producing heme, a component of hemoglobin, our aim was to see if we could lower blood levels of PPIX and improve liver function. The study observed these patients over periods extending up to eight years. Though case reports suggested potential benefits of iron supplementation—like reducing PPIX levels and alleviating liver damage—our findings pointed out that monitoring the dosage and long-term effects is essential for safety.
We also noted that there seems to be a need for standardized treatment protocols and guidelines to optimize care for XLEPP patients. As the research progresses, it remains crucial to reevaluate and understand the broader impact of iron treatment on liver health in this unique group of patients.
By providing iron, which is essential for producing heme, a component of hemoglobin, our aim was to see if we could lower blood levels of PPIX and improve liver function. The study observed these patients over periods extending up to eight years. Though case reports suggested potential benefits of iron supplementation—like reducing PPIX levels and alleviating liver damage—our findings pointed out that monitoring the dosage and long-term effects is essential for safety.
We also noted that there seems to be a need for standardized treatment protocols and guidelines to optimize care for XLEPP patients. As the research progresses, it remains crucial to reevaluate and understand the broader impact of iron treatment on liver health in this unique group of patients.
Read More
Most Useful Reviews
8.8
Improved absorption
The iron in this preparation is bisglycinate, which does not cause the usual side effects of iron supplements such as constipation, diarrhoea, or that unpleasant rusty nail sensation affecting the liver. It can even be taken by pregnant and lactating women. The absorption is significantly higher than that of gluconate, helping prevent iron deficiency anaemia and support ferritin levels effectively.
Read More
9
Feeling revitalised
After struggling with fatigue for years, I decided to try iron supplementation. Despite never being diagnosed with anaemia, I grew concerned about my liver yet still opted to take it. I noticed improvements within days, enabling me to tackle housework with newfound energy. While I monitor for excess iron, I am pleased with the results so far.
Read More
8.8
Dizziness alleviated
I began taking it due to chronic anaemia. Since I dislike liver, rich in iron, I opted for this supplement. After starting, I no longer feel dizzy during my period. I plan to continue taking it.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8
- All Researches
9
Rubiadin reduces liver iron overload
Rubiadin Mediates the Upregulation of Hepatic Hepcidin and Alleviates Iron Overload via BMP6/SMAD1/5/9-Signaling Pathway.
Study highly relevant to liver disease
We explored the effects of rubiadin, a beneficial compound derived from a Chinese herb, on iron metabolism and its implications for liver disease. Recognizing the challenges posed by iron overload diseases, we aimed to discover a safe approach to manage excessive iron accumulation in the body. Through experiments involving various analyses, we observed that rubiadin significantly downregulated proteins that are typically elevated in conditions of high iron, such as transferrin receptor 1 and ferroportin 1.
Furthermore, when we administered rubiadin to mice with iron overload, it resulted in decreased serum and duodenal iron levels and an increase in hepcidin mRNA expression in the liver. This suggests that rubiadin may not only help the body regulate iron better but might also protect against the harmful effects of excess iron.
Our research also delved into the mechanisms behind these effects. We found that rubiadin-induced hepcidin expression was mediated through a specific signaling pathway involving bone morphogenetic protein 6 (BMP6) and SMAD proteins. The ability of rubiadin to enhance hepcidin levels points toward a promising natural strategy for tackling iron overload in liver diseases and could have broader implications for treating related conditions.
Furthermore, when we administered rubiadin to mice with iron overload, it resulted in decreased serum and duodenal iron levels and an increase in hepcidin mRNA expression in the liver. This suggests that rubiadin may not only help the body regulate iron better but might also protect against the harmful effects of excess iron.
Our research also delved into the mechanisms behind these effects. We found that rubiadin-induced hepcidin expression was mediated through a specific signaling pathway involving bone morphogenetic protein 6 (BMP6) and SMAD proteins. The ability of rubiadin to enhance hepcidin levels points toward a promising natural strategy for tackling iron overload in liver diseases and could have broader implications for treating related conditions.
Read More
7
Iron's impact on liver disease
Long-term iron supplementation in four patients with X-linked erythropoietic protoporphyria: associations with serum proteins and erythrocyte protoporphyrin levels-a single-centre retrospective study.
Focus on liver treatment effects
We explored the long-term effects of iron supplementation in four patients suffering from X-linked erythropoietic protoporphyria (XLEPP), a rare genetic disorder that can lead to serious liver problems due to the buildup of a substance called protoporphyrin IX (PPIX) in the blood. This condition often causes severe photosensitivity and can result in liver damage, which, in some cases, may necessitate a liver transplant.
By providing iron, which is essential for producing heme, a component of hemoglobin, our aim was to see if we could lower blood levels of PPIX and improve liver function. The study observed these patients over periods extending up to eight years. Though case reports suggested potential benefits of iron supplementation—like reducing PPIX levels and alleviating liver damage—our findings pointed out that monitoring the dosage and long-term effects is essential for safety.
We also noted that there seems to be a need for standardized treatment protocols and guidelines to optimize care for XLEPP patients. As the research progresses, it remains crucial to reevaluate and understand the broader impact of iron treatment on liver health in this unique group of patients.
By providing iron, which is essential for producing heme, a component of hemoglobin, our aim was to see if we could lower blood levels of PPIX and improve liver function. The study observed these patients over periods extending up to eight years. Though case reports suggested potential benefits of iron supplementation—like reducing PPIX levels and alleviating liver damage—our findings pointed out that monitoring the dosage and long-term effects is essential for safety.
We also noted that there seems to be a need for standardized treatment protocols and guidelines to optimize care for XLEPP patients. As the research progresses, it remains crucial to reevaluate and understand the broader impact of iron treatment on liver health in this unique group of patients.
Read More
User Reviews
USERS' SCORE
Good
Based on 6 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
8.8
Improved absorption
The iron in this preparation is bisglycinate, which does not cause the usual side effects of iron supplements such as constipation, diarrhoea, or that unpleasant rusty nail sensation affecting the liver. It can even be taken by pregnant and lactating women. The absorption is significantly higher than that of gluconate, helping prevent iron deficiency anaemia and support ferritin levels effectively.
Read More
9
Feeling revitalised
After struggling with fatigue for years, I decided to try iron supplementation. Despite never being diagnosed with anaemia, I grew concerned about my liver yet still opted to take it. I noticed improvements within days, enabling me to tackle housework with newfound energy. While I monitor for excess iron, I am pleased with the results so far.
Read More
8.8
Dizziness alleviated
I began taking it due to chronic anaemia. Since I dislike liver, rich in iron, I opted for this supplement. After starting, I no longer feel dizzy during my period. I plan to continue taking it.
8.8
Iron absorption aid
Excellent for those requiring iron. This type reduces constipation unlike other iron supplements. However, utilise with caution if not needed, as excess can lead to liver disease and other complications.
8.8
Caution advised
A superb choice for those in need of iron, this variant lessens constipation, unlike other supplements. It's essential to avoid use if unnecessary, as excessive iron can trigger liver disease and various issues. Women, due to menstruation, may benefit from it to manage iron levels.
Read More
